Various studies have been reported on different pulmonary drug delivery system but pulmonary microspheres are one of the convenient drug delivery system due to its efficiency to deliver drug. In the present study, microspheres of ciprofloxacin hydrochloride were prepared from biodegradable polymer PLGA (75:25) by using spray drying technique. These formulations were studied and compared on the basis of their polymeric concentration with the help of different evaluation parameters. Study suggest that by using optimum concentration of polymers in the formulations of pulmonary microspheres we can achieve the alveolar level for drug deposition and spray drying is one of the convenient method to formulate pulmonary microspheres.
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